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Search for "model organisms" in Full Text gives 7 result(s) in Beilstein Journal of Organic Chemistry.
Protein–protein interactions in bacteria: a promising and challenging avenue towards the discovery of new antibiotics
Beilstein J. Org. Chem. 2018, 14, 2881–2896, doi:10.3762/bjoc.14.267
- forge the bacterial interactome [35]. However, despite the potential of these bacterial PPI maps, they have only been studied in detail in a few microorganisms including Escherichia coli (one of the best-studied model organisms in this field) [36][37][38][39], Mycobacterium tuberculosis [40
Acyl-group specificity of AHL synthases involved in quorum-sensing in Roseobacter group bacteria
Beilstein J. Org. Chem. 2018, 14, 1309–1316, doi:10.3762/bjoc.14.112
- . coli and the purified recombinant enzymes were tested with different precursors to probe their selectivity. Both model organisms of the Roseobacter group, P. inhibens (formerly P. gallaeciensis [25]) DSM17395 and Dinoroseobacter shibae DFL-12, were investigated, together with closely related P
Isoxazole derivatives as new nitric oxide elicitors in plants
Beilstein J. Org. Chem. 2017, 13, 659–664, doi:10.3762/bjoc.13.65
- of both NO and ROS was proven by fluorescence microscopy using specific fluorescence indicators that help to exactly define the sites of generation. We used Arabidopsis thaliana wild type seeds, cultivated for six weeks in laboratory in Arasystem [60]. Arabidopsis thaliana was selected as model
- organisms for NO inductors because this is the flowering plant with the largest amount of knowledge on cellular and molecular biology and it has a relatively short life cycle. The Arabidopsis leaves were sprayed with fine suspensions of isoxazole inductors 6–11 at two different concentrations (10 μg/mL and
Antibiotics from predatory bacteria
Beilstein J. Org. Chem. 2016, 12, 594–607, doi:10.3762/bjoc.12.58
- small fraction of the corresponding secondary metabolomes have been explored. Even in case of model organisms, which were subject of extensive chemical investigations, such as M. xanthus DK1622, the products of most biosynthetic pathways await their discovery. On the other hand, there is now strong
Synthesis and bioactivity of analogues of the marine antibiotic tropodithietic acid
Beilstein J. Org. Chem. 2014, 10, 1796–1801, doi:10.3762/bjoc.10.188
- their biosynthesis is unknown [10]. TDA exhibits a strong antibiotic activity against a broad spectrum of bacteria including alpha- and gammaproteobacteria, flavobacteria and actinobacteria [11], but not against the eukaryotic model organisms Artemia sp. and Caenorhabditis elegans, suggesting P
From bead to flask: Synthesis of a complex β-amido-amide for probe-development studies
Beilstein J. Org. Chem. 2013, 9, 260–264, doi:10.3762/bjoc.9.31
- easily accessible for early stage studies of these compounds in vitro and in vivo using model organisms. p21 determines the fate of DNA-damaged [13] cells. Retrosynthetic analysis of LLW62 (1) from acid 7 (A) or aldehyde 11 (B). Attempted synthesis of aldehyde 4 from nitrile 6. (A) Synthesis of 4 from
Hydrophobic analogues of rhodamine B and rhodamine 101: potent fluorescent probes of mitochondria in living C. elegans
Beilstein J. Org. Chem. 2012, 8, 2156–2165, doi:10.3762/bjoc.8.243
- ; fluorescence; fusion; imaging; in vivo; microscopy; mitochondria; model organisms; organelle; rhodamine; spectroscopy; Introduction Fluorescent molecular probes represent critical tools for studies of chemical biology [1]. These compounds allow the creation of sensitive enzyme substrates, sensors of a wide
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